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Hiroshi Hiasa Selected Research

Type II DNA Topoisomerases (Topoisomerase II)

1/2019Novel N-1 substituted fluoroquinolones inhibit human topoisomerase I activity and exhibit anti-proliferative activity.
8/2012Inhibition of human topoisomerases I and II by simocyclinone D8.
8/2012Novel acridine-based agents with topoisomerase II inhibitor activity suppress mesothelioma cell proliferation and induce apoptosis.
8/2009On the role of topoisomerase I in mediating the cytotoxicity of 9-aminoacridine-based anticancer agents.
1/2009Novel acridine-based compounds that exhibit an anti-pancreatic cancer activity are catalytic inhibitors of human topoisomerase II.
1/2008Acridine-based agents with topoisomerase II activity inhibit pancreatic cancer cell proliferation and induce apoptosis.
8/2006Synthesis and evaluation of acridine- and acridone-based anti-herpes agents with topoisomerase activity.

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Hiroshi Hiasa Research Topics

Disease

8Neoplasms (Cancer)
06/2019 - 08/2009
4Pancreatic Neoplasms (Pancreatic Cancer)
08/2012 - 01/2008
3Bacterial Infections (Bacterial Infection)
01/2020 - 07/2010
2Poisoning
05/2020 - 01/2019
2Malignant Mesothelioma
08/2012 - 02/2010
2Infections
01/2009 - 08/2006
1Colorectal Neoplasms (Colorectal Cancer)
01/2019
1Mesothelioma
08/2012
1Virus Diseases (Viral Diseases)
08/2006

Drug/Important Bio-Agent (IBA)

7Type II DNA Topoisomerases (Topoisomerase II)IBA
01/2019 - 08/2006
5FluoroquinolonesIBA
05/2020 - 07/2010
4AcridinesIBA
08/2012 - 08/2006
3Pharmaceutical PreparationsIBA
11/2013 - 01/2009
3PoisonsIBA
08/2012 - 01/2009
2Anti-Bacterial Agents (Antibiotics)IBA
01/2020 - 11/2013
2Type I DNA Topoisomerases (Topoisomerase I)IBA
01/2019 - 08/2009
2DNA (Deoxyribonucleic Acid)IBA
01/2019 - 08/2012
2Antineoplastic Agents (Antineoplastics)IBA
01/2018 - 08/2006
1Gatifloxacin (Zymar)FDA Link
05/2020
1Ciprofloxacin (Cipro)FDA LinkGeneric
05/2020
1MacrolidesIBA
05/2020
1Azithromycin (Zithromax)FDA LinkGeneric
05/2020
1Proteins (Proteins, Gene)FDA Link
05/2020
1DNA Topoisomerase IV (Topoisomerase IV)IBA
01/2020
1DNA TopoisomerasesIBA
01/2020
1diphenyl (biphenyl)IBA
06/2019
1Fluorouracil (Carac)FDA LinkGeneric
01/2019
1Etoposide (VP 16)FDA LinkGeneric
08/2012
1EnzymesIBA
08/2012
1Topoisomerase II InhibitorsIBA
08/2012
1Doxorubicin (Adriamycin)FDA LinkGeneric
08/2012
1XanthenesIBA
02/2010
1Cisplatin (Platino)FDA LinkGeneric
02/2010
1Aminacrine (Aminoacridine)IBA
01/2009
1QuinolonesIBA
01/2009
1AgarIBA
01/2009
1Superhelical DNA (Supercoiled DNA)IBA
08/2006
1NucleosidesIBA
08/2006
1Antiviral Agents (Antivirals)IBA
08/2006

Therapy/Procedure

1Precision Medicine
01/2018
1Therapeutics
08/2009